On the reactivity of mRNA Cap0: C–H oxidative addition of 7-methylguanosine to Pt0 and base pairing studies

Maria Inês P. S. Leitão; Carmen Gonzalez; Giulia Francescato; Zuzanna Filipiak; Ana Petronilho

doi:10.1039/D0CC06075E

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On the reactivity of mRNA Cap0: C–H oxidative addition of 7-methylguanosine to Pt⁰ and base pairing studies†

Maria Inês P. S. Leitão,

^a Carmen Gonzalez,

^a Giulia Francescato,^a Zuzanna Filipiak^a and Ana Petronilho

*^a

Author affiliations

* Corresponding authors

^a ITQB NOVA – Instituto de Tecnologia Química e Biológica António Xavier, Avd. Da República s/n, 2780-157 Oeiras, Portugal
E-mail: ana.petronilho@itqb.unl.pt

Abstract

7-Methylguanosine, whose lability to form an ylide/NHC has been known for decades, reacts with [Pt(PPh₃)₄] via C–H oxidative addition to yield a hydrido–Pt^II carbene complex. ¹H NMR studies on Watson–Crick base-pairs showed no significant effect of metallation.

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Article information

DOI: https://doi.org/10.1039/D0CC06075E
Article type: Communication
Submitted: 09 Sep 2020
Accepted: 02 Oct 2020
First published: 05 Oct 2020

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Chem. Commun., 2020,56, 13365-13368

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On the reactivity of mRNA Cap0: C–H oxidative addition of 7-methylguanosine to Pt⁰ and base pairing studies

M. I. P. S. Leitão, C. Gonzalez, G. Francescato, Z. Filipiak and A. Petronilho, Chem. Commun., 2020, 56, 13365 DOI: 10.1039/D0CC06075E

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