Issue 88, 2020
From the journal:

Chemical Communications

Fluorescence resonance energy transfer-based DNA framework assembled split G-quadruplex nanodevices for microRNA sensing†

Gaoxing Su, ORCID logo ‡a   Min Zhu,‡a   Mengting Xu,a   Jianbin Pan, ORCID logo b   Yao Zhou,a   Hongyu Zhou,c   Wei S. Zhang,a   Yanli Tong ORCID logo *d  and  Yanyan Yu ORCID logo *a  

* Corresponding authors

a School of Pharmacy, Nantong University, Nantong, Jiangsu 226001, China
E-mail: yuyanyan@ntu.edu.cn

b State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China

c Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou 510006, China

d Guangdong Second Provincial General Hospital, Guangzhou, Guangdong 510317, China
E-mail: tongh2008@126.com

Abstract

A DNA framework assembled split G4 nanodevice was fabricated to realize microRNA imaging in living HeLa cells. After hybridization with the target, the separated G4 segments underwent structural transformations, which could initiate fluorescence resonance energy transfer (FRET) processes. Our design may pave a novel way to facilitate applications of the G4 motif.

Graphical abstract: Fluorescence resonance energy transfer-based DNA framework assembled split G-quadruplex nanodevices for microRNA sensing

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Article information

DOI
https://doi.org/10.1039/D0CC06054B
Article type
Communication
Submitted
08 Sep 2020
Accepted
01 Oct 2020
First published
14 Oct 2020

Chem. Commun., 2020,56, 13583-13586

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Fluorescence resonance energy transfer-based DNA framework assembled split G-quadruplex nanodevices for microRNA sensing

G. Su, M. Zhu, M. Xu, J. Pan, Y. Zhou, H. Zhou, W. S. Zhang, Y. Tong and Y. Yu, Chem. Commun., 2020, 56, 13583 DOI: 10.1039/D0CC06054B

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