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Issue 89, 2020
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Effect of charge status on the ion transport and antimicrobial activity of synthetic channels

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Abstract

A class of unimolecular channels formed by pillararene–gramicidin hybrid molecules are presented. The charge status of the peptide domain in these channels has a significant impact on their ion transport and antimicrobial activity. These channels exhibited different membrane-association abilities between microbial cells and mammalian cells. One of the channels displayed a higher antimicrobial activity towards S. aureus (IC50 = 0.55 μM) and negligible hemolytic toxicity, showing potential to serve as a systemic antibiotic.

Graphical abstract: Effect of charge status on the ion transport and antimicrobial activity of synthetic channels

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Article information


Submitted
24 Aug 2020
Accepted
09 Oct 2020
First published
09 Oct 2020

Chem. Commun., 2020,56, 13796-13799
Article type
Communication

Effect of charge status on the ion transport and antimicrobial activity of synthetic channels

P. Xin, L. Zhao, L. Mao, L. Xu, S. Hou, H. Kong, H. Fang, H. Zhu, T. Jiang and C. Chen, Chem. Commun., 2020, 56, 13796
DOI: 10.1039/D0CC05730D

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