Issue 92, 2020
From the journal:

Chemical Communications

Fluorogenic Pt complexes distinguish the quantity and folding behavior of RNA G-quadruplexes between live cancerous and healthy cells†

Lei He, ORCID logo bc   Zhenyu Meng,c   Qianqian Guo,a   Xiangyang Wu,c   Marie-Paule Teulade-Fichou,cd   Edwin Kok Lee Yeow ORCID logo c  and  Fangwei Shao ORCID logo *a  

* Corresponding authors

a Zhejiang University-University of Illinois at Urbana-Champaign Institute, Zhejiang University, Haining, China
E-mail: fwshao@zju.edu.cn

b State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China

c School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore

d CNRS UMR 9187, INSERM U1196, Institut Curie, PSL Research University and Université Paris Sud, Université Paris Saclay, Orsay, France

Abstract

Two Pt complexes with high quantum yields and photostability, and low cytotoxicity, were developed to track RNA G-quadruplexes (GQs) in live cells. Higher number and intensity, and longer lifetime of fluorescent foci in cancer cells than those in healthy cells suggest that the quantity and folding dynamics of RNA GQs could not only correlate to their biological functions, but be two novel biomarkers to characterize cancerous cells.

Graphical abstract: Fluorogenic Pt complexes distinguish the quantity and folding behavior of RNA G-quadruplexes between live cancerous and healthy cells

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Article information

DOI
https://doi.org/10.1039/D0CC05622G
Article type
Communication
Submitted
18 Aug 2020
Accepted
27 Oct 2020
First published
27 Oct 2020

Chem. Commun., 2020,56, 14459-14462

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Fluorogenic Pt complexes distinguish the quantity and folding behavior of RNA G-quadruplexes between live cancerous and healthy cells

L. He, Z. Meng, Q. Guo, X. Wu, M. Teulade-Fichou, E. K. L. Yeow and F. Shao, Chem. Commun., 2020, 56, 14459 DOI: 10.1039/D0CC05622G

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