Three-Component Ruthenium-catalyzed Remote C-H Functionalization of 8-aminoquinoline amides
Multicomponent reactions can efficiently construct complex molecular structures from simple precursors. Herein, a novel ruthenium-catalyzed three-component highly selective remote C-H functionalization of 8-aminoquinoline amides has been described. The reaction tolerates a wide range of function group, producing arylation/difluoroalkylation products of olefins with potential biological activity and pharmaceutical value. Radical scavenging experiment and radical clock experiment show a free radical process is involved and H/D Exchange experiment suggests that the reaction might involve ortho-C−H activation of the aromatic ring. Possible mechanism is proposed.