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Issue 92, 2020
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Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling

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Abstract

Novel tetraplatinated metalloporphyrin-based photosensitizers (PSs) are reported, which show excellent phototoxic indexes (PIs) up to 5800 against HeLa cells, which is, to the best of our knowledge, the highest value reported for any porphyrin so far. Furthermore, 67Zn isotope labelling allowed the determination of the ratio of zinc to platinum inside the cells using ICP-MS.

Graphical abstract: Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling

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Article information


Submitted
30 Jul 2020
Accepted
19 Oct 2020
First published
20 Oct 2020

This article is Open Access

Chem. Commun., 2020,56, 14373-14376
Article type
Communication

Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling

R. Rubbiani, W. Wu, A. Naik, M. Larocca, L. Schneider, R. Padrutt, V. Babu, C. König, D. Hinger, C. Maake, S. Ferrari, G. Gasser and B. Spingler, Chem. Commun., 2020, 56, 14373
DOI: 10.1039/D0CC05196A

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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