Mitochondria-targeting NO gas nanogenerator for augmenting mild photothermal therapy in the NIR-II biowindow

Canchen Wu; Danqi Wang; Moupan Cen; Leyu Cao; Yue Ding; Jin Wang; Xiaolei Yuan; Yang Wang; Tingting Chen; Yong Yao

doi:10.1039/D0CC05125J

Mitochondria-targeting NO gas nanogenerator for augmenting mild photothermal therapy in the NIR-II biowindow†

Canchen Wu,‡^a Danqi Wang,‡^a Moupan Cen,^a Leyu Cao,^a Yue Ding,^a Jin Wang,^a Xiaolei Yuan,

^a Yang Wang,

*^a Tingting Chen*^a and Yong Yao

*^a

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* Corresponding authors

^a School of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226019, China
E-mail: ywang85@ntu.edu.cn, ttchen1980@126.com, yaoyong1986@ntu.edu.cn

Abstract

An intelligent nitric oxide gas-releasing nanoplatform based on CuS-nanoplates has been designed to overcome the heat endurance of tumor cells by the inhibition of HSP90 expression with the released NO gas in mitochondria and thereby realize enhanced PTT under mild temperature conditions.

Chemical Communications

Mitochondria-targeting NO gas nanogenerator for augmenting mild photothermal therapy in the NIR-II biowindow†

Abstract

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Mitochondria-targeting NO gas nanogenerator for augmenting mild photothermal therapy in the NIR-II biowindow

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