Issue 75, 2020

Cu(ii)-Catalysed β-silylation of dehydroalanine residues in peptides and proteins

Abstract

We report the efficient and selective Cu(II)-catalysed β-silylation of naturally occurring dehydroalanine (Dha) residues in various ribosomally synthesized and post-translationally modified peptides (RiPPs). The method is also applicable to proteins, as was shown by the modification of a Dha residue that was chemically introduced into Small Ubiquitin-like Modifier (SUMO).

Graphical abstract: Cu(ii)-Catalysed β-silylation of dehydroalanine residues in peptides and proteins

Supplementary files

Article information

Article type
Communication
Submitted
22 Jul 2020
Accepted
10 Aug 2020
First published
10 Aug 2020
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2020,56, 11058-11061

Cu(II)-Catalysed β-silylation of dehydroalanine residues in peptides and proteins

R. H. de Vries and G. Roelfes, Chem. Commun., 2020, 56, 11058 DOI: 10.1039/D0CC05026A

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