Issue 77, 2020

Synthesis of new tetracyclic benzodiazepine-fused isoindolinones using recyclable mesoporous silica nanoparticles

Abstract

Pseudo natural products (NPs) feature structural novelty and diversity and thus are a new source of lead compounds for drug discovery. We first report the mesoporous silica nanoparticles (MSNs)-catalyzed de novo combination of benzodiazepine and isoindolinone, giving tetracyclic benzodiazepine-fused isoindolinone pseudo natural products (21 examples, 55–91% yields). The work also demonstrates that MSNs are efficient acidic catalysts for multi-component reactions.

Graphical abstract: Synthesis of new tetracyclic benzodiazepine-fused isoindolinones using recyclable mesoporous silica nanoparticles

Supplementary files

Article information

Article type
Communication
Submitted
15 Jul 2020
Accepted
15 Aug 2020
First published
17 Aug 2020

Chem. Commun., 2020,56, 11461-11464

Synthesis of new tetracyclic benzodiazepine-fused isoindolinones using recyclable mesoporous silica nanoparticles

S. Yuan, Y. Yue, D. Zhang, J. Zhang, B. Yu and H. Liu, Chem. Commun., 2020, 56, 11461 DOI: 10.1039/D0CC04875E

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