Issue 76, 2020

Weak coordinated nitrogen functionality enabled regioselective C–H alkynylation via Pd(ii)/mono-N-protected amino acid catalysis

Abstract

The exploration of weak coordinated amine derivative enabled regioselective C–H functionalization remains challenging due to the elusive achievement of reactivity and selectivity simultaneously. Herein, regioselective C–H alkynylation of various readily transformable nitrogen functionalities was developed with great efficiency, with the assistance of the mono-N-protected amino acid (MPAA) ligand via Pd(II) catalysis proceeding via 5, 6 and 7-membered palladacycle intermediates.

Graphical abstract: Weak coordinated nitrogen functionality enabled regioselective C–H alkynylation via Pd(ii)/mono-N-protected amino acid catalysis

Supplementary files

Article information

Article type
Communication
Submitted
09 Jul 2020
Accepted
13 Aug 2020
First published
14 Aug 2020

Chem. Commun., 2020,56, 11255-11258

Weak coordinated nitrogen functionality enabled regioselective C–H alkynylation via Pd(II)/mono-N-protected amino acid catalysis

B. Liu, W. Ouyang, J. Nie, Y. Gao, K. Feng, Y. Huo, Q. Chen and X. Li, Chem. Commun., 2020, 56, 11255 DOI: 10.1039/D0CC04739B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements