Issue 87, 2020
From the journal:

Chemical Communications

pH-Responsive dopamine-based nanoparticles assembled via Schiff base bonds for synergistic anticancer therapy†

Hong Li,a   Yuanyuan Zhao,a   Yi Jia, ORCID logo *b   Gang Chen,a   Junxia Peng ORCID logo c  and  Junbai Li ORCID logo *bd  

* Corresponding authors

a Shaanxi Province Key Laboratory of Environmental Pollution Control and Reservoir Protection Technology of Oilfields, College of Chemistry and Chemical Engineering, Xi’an Shiyou University, Xi’an 710065, China

b Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: jbli@iccas.ac.cn, jiayi@iccas.ac.cn

c Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710119, China

d University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

The dynamic Schiff base bond is exploited to construct monodisperse dopamine-based nanoparticles with autofluorescence and pH-sensitivity. This allows facile monitoring and pH-responsive drug release in the acidic tumor microenvironment. Anticancer drugs doxorubicin and a photosensitizer chlorin e6 are further loaded into the nanoparticles and synergistic anticancer efficacy is achieved.

Graphical abstract: pH-Responsive dopamine-based nanoparticles assembled via Schiff base bonds for synergistic anticancer therapy

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Article information

DOI
https://doi.org/10.1039/D0CC04656F
Article type
Communication
Submitted
06 Jul 2020
Accepted
25 Sep 2020
First published
26 Sep 2020

Chem. Commun., 2020,56, 13347-13350

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pH-Responsive dopamine-based nanoparticles assembled via Schiff base bonds for synergistic anticancer therapy

H. Li, Y. Zhao, Y. Jia, G. Chen, J. Peng and J. Li, Chem. Commun., 2020, 56, 13347 DOI: 10.1039/D0CC04656F

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