Ultrasensitive analysis of microRNAs with gold nanoparticle-decorated molybdenum disulfide nanohybrid-based multilayer nanoprobes

Shao Su; Qian Sun; Jianfeng Ma; Dan Zhu; Fei Wang; Jie Chao; Chunhai Fan; Qian Li; Lianhui Wang

doi:10.1039/D0CC03845H

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Ultrasensitive analysis of microRNAs with gold nanoparticle-decorated molybdenum disulfide nanohybrid-based multilayer nanoprobes†

Shao Su,‡^a Qian Sun,‡^a Jianfeng Ma,^a Dan Zhu,^a Fei Wang,^b Jie Chao,^a Chunhai Fan,^b Qian Li*^b and Lianhui Wang

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory for Organic Electronics and Information Displays (KLOEID) & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China
E-mail: iamlhwang@njupt.edu.cn

^b School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
E-mail: liqian2018@sjtu.edu.cn

Abstract

The nanoprobe-based signal amplification strategy is a powerful way to ultrasensitively detect biomolecules. Herein, a gold nanoparticle-decorated molybdenum disulfide (MoS₂–AuNP)-based multilayer nanoprobe (MLNP) was designed for ultrasensitive analysis of microRNA-21 (miRNA-21). The MLNP-amplified electrochemical biosensor exhibited an ultrawide dynamic range (10 aM–1 μM) and an ultralow detection limit (38 aM) for target miRNA-21 analysis. Furthermore, this biosensor can determine miRNA-21 expression in cell lysates of 100 human cervical cancer (HeLa) cells. Our results demonstrate that MoS₂–AuNP nanocomposites have great potential in constructing biosensors for target molecule analysis.

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DOI: https://doi.org/10.1039/D0CC03845H
Article type: Communication
Submitted: 01 Jun 2020
Accepted: 01 Jul 2020
First published: 01 Jul 2020

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Chem. Commun., 2020,56, 9012-9015

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Ultrasensitive analysis of microRNAs with gold nanoparticle-decorated molybdenum disulfide nanohybrid-based multilayer nanoprobes

S. Su, Q. Sun, J. Ma, D. Zhu, F. Wang, J. Chao, C. Fan, Q. Li and L. Wang, Chem. Commun., 2020, 56, 9012 DOI: 10.1039/D0CC03845H

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Chemical Communications

Ultrasensitive analysis of microRNAs with gold nanoparticle-decorated molybdenum disulfide nanohybrid-based multilayer nanoprobes†

Abstract

Supplementary files

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Ultrasensitive analysis of microRNAs with gold nanoparticle-decorated molybdenum disulfide nanohybrid-based multilayer nanoprobes

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