Issue 86, 2020
From the journal:

Chemical Communications

Step and redox efficient nitroarene to indole synthesis†

Bünyamin Özkaya, ORCID logo a   Christina L. Bub ORCID logo a  and  Frederic W. Patureau ORCID logo *a  

* Corresponding authors

a Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany
E-mail: Frederic.patureau@rwth-aachen.de
Web: https://www.patureau-oc-rwth-aachen.de

Abstract

Step and redox efficiencies are a rising priority in synthetic method development, in order to make synthetic processes more sustainable and more affordable. Herein, a step and redox efficient nitroarene to indole synthesis is developed, in sharp contrast to the rich literature on the construction of indoles. Elemental zinc was found to be the best terminal reductant.

Graphical abstract: Step and redox efficient nitroarene to indole synthesis

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Article information

DOI
https://doi.org/10.1039/D0CC03258A
Article type
Communication
Submitted
06 May 2020
Accepted
13 Jul 2020
First published
06 Oct 2020
This article is Open Access
Creative Commons BY license

Chem. Commun., 2020,56, 13185-13188

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Step and redox efficient nitroarene to indole synthesis

B. Özkaya, C. L. Bub and F. W. Patureau, Chem. Commun., 2020, 56, 13185 DOI: 10.1039/D0CC03258A

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