A structurally precise AgxAu25−x nanocluster based cancer theranostic platform with tri-targeting/in situ O2-generation/aggregation enhanced fluorescence imaging/photothermal–photodynamic therapies

Ying Yang; Yinlong Zhou; Shuxin Wang; Xueyan Wang; Xuan Liu; Anjian Xie; Yuhua Shen; Manzhou Zhu

doi:10.1039/D0CC02946G

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A structurally precise Ag_xAu_25−x nanocluster based cancer theranostic platform with tri-targeting/in situ O₂-generation/aggregation enhanced fluorescence imaging/photothermal–photodynamic therapies†

Ying Yang,

^a Yinlong Zhou,^a Shuxin Wang,

^a Xueyan Wang,^a Xuan Liu,^a Anjian Xie,^a Yuhua Shen

*^a and Manzhou Zhu

*^a

Author affiliations

* Corresponding authors

^a College of Chemistry and Chemical Engineering, Institute of Physical Science and Information Technology, Anhui University, Hefei 230601, P. R. China
E-mail: s_yuhua@163.com, zmz@ahu.edu.cn

Abstract

The photothermal and photodynamic performances of structurally precise oil-soluble Ag_xAu_25−x (x ≤ 13) nanoclusters were first explored and they were solubilized into new assemblies to form a versatile cancer theranostic platform with tri-targeting/in situ O₂-generation/aggregation enhanced fluorescence imaging/photothermal–photodynamic therapy effects, which will provide an important reference for precision theranostics at the atomic level in future.

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Article information

DOI: https://doi.org/10.1039/D0CC02946G
Article type: Communication
Submitted: 23 Apr 2020
Accepted: 20 Jul 2020
First published: 20 Jul 2020

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Chem. Commun., 2020,56, 9842-9845

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A structurally precise Ag_xAu_25−x nanocluster based cancer theranostic platform with tri-targeting/in situ O₂-generation/aggregation enhanced fluorescence imaging/photothermal–photodynamic therapies

Y. Yang, Y. Zhou, S. Wang, X. Wang, X. Liu, A. Xie, Y. Shen and M. Zhu, Chem. Commun., 2020, 56, 9842 DOI: 10.1039/D0CC02946G

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Chemical Communications