A two-photon fluorescent probe for sensitive detection and imaging of γ-glutamyl transpeptidase

Ruijin Huo; Xiuli Zheng; Weimin Liu; Liping Zhang; Jiasheng Wu; Fan Li; Wenjun Zhang; Chun-Sing Lee; Pengfei Wang

doi:10.1039/D0CC02750B

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A two-photon fluorescent probe for sensitive detection and imaging of γ-glutamyl transpeptidase†

Ruijin Huo,

‡^ab Xiuli Zheng,

‡^a Weimin Liu,

*^ab Liping Zhang,^ab Jiasheng Wu,^a Fan Li,^a Wenjun Zhang,

^c Chun-Sing Lee

^c and Pengfei Wang

*^ab

Author affiliations

* Corresponding authors

^a Key Laboratory of Photochemical Conversion and Optoelectronic Materials and City U-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: wmliu@mail.ipc.ac.cn, wangpf@mail.ipc.ac.cn

^b School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, P. R. China

^c Center Of Super-Diamond and Advanced Films (COSDAF) & Department of Materials Science and Engineering, City University of Hong Kong, Hong Kong SAR, People's Republic of China

Abstract

A GGT-activated two-photon fluorescent probe (4F-2CN–GSH) was developed based on a cascade reaction. 4F-2CN–GSH could selectivily detect GGT with low detection limit and distinguish ovarian cancer cells from normal cells using both one-photon and two-photon fluorescence imaging.

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Article information

DOI: https://doi.org/10.1039/D0CC02750B
Article type: Communication
Submitted: 26 Apr 2020
Accepted: 04 Aug 2020
First published: 05 Aug 2020

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Chem. Commun., 2020,56, 10902-10905

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A two-photon fluorescent probe for sensitive detection and imaging of γ-glutamyl transpeptidase

R. Huo, X. Zheng, W. Liu, L. Zhang, J. Wu, F. Li, W. Zhang, C. Lee and P. Wang, Chem. Commun., 2020, 56, 10902 DOI: 10.1039/D0CC02750B

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Chemical Communications

A two-photon fluorescent probe for sensitive detection and imaging of γ-glutamyl transpeptidase†

Abstract

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A two-photon fluorescent probe for sensitive detection and imaging of γ-glutamyl transpeptidase

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