Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds†
Hualong
Song, 
a
Nicola J.
Rogers,
*a
Viktor
Brabec,
*c
Guy J.
Clarkson,
a
James P. C.
Coverdale,
a
Hana
Kostrhunova,
c
Roger M.
Phillips,
b
Miles
Postings,
a
Samantha L.
Shepherd
b
and
Peter
Scott
*a
a
Nicola J.
Rogers,
*a
Viktor
Brabec,
*c
Guy J.
Clarkson,
a
James P. C.
Coverdale,
a
Hana
Kostrhunova,
c
Roger M.
Phillips,
b
Miles
Postings,
a
Samantha L.
Shepherd
b
and
Peter
Scott
*a
Abstract
Functionalised triazole aldehydes are used in the highly selective self-assembly of water-compatible, optically pure, low symmetry Fe(II)- and Zn(II)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cell lines, accompanied by excellent selectivity versus non-cancerous cells and potential for synergistic combinatorial therapy with cisplatin.
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