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We demonstrate that the Ce reactivity of CeO2 towards H2O2 is dictated by its local structure and electron density. More than 2400% increase in peroxidase-like activity has been achieved on the (100) surface for glucose detection due to the promoted H2O2 adsorption and subsequent activation by the electron-rich Ce species.

Graphical abstract: Chemical state tuning of surface Ce species on pristine CeO2 with 2400% boosting in peroxidase-like activity for glucose detection

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