Issue 45, 2020
From the journal:

Chemical Communications

Nanogel receptors for high isoelectric point protein detection: influence of electrostatic and covalent polymer–protein interactions†

Marissa E. Wechsler,ab   H. K. H. Jocelyn Dang,b   Samuel D. Dahlhauser,c   Susana P. Simmonds,b   James F. Reuther,cd   Jordyn M. Wyse,b   Abigail N. VandeWalle,c   Eric V. Anslyn ORCID logo *c  and  Nicholas A. Peppas ORCID logo *abefg  

* Corresponding authors

a Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX, USA

b Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA

c Department of Chemistry, The University of Texas at Austin, Austin, TX, USA
E-mail: anslyn@austin.utexas.edu

d Department of Chemistry, University of Massachusetts Lowell, Lowell, MA, USA

e McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA
E-mail: peppas@che.utexas.edu

f Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA

g Department of Surgery and Perioperative Care, Dell Medical School, The University of Texas at Austin, Austin, TX, USA

Abstract

An aldehyde acrylate-based functional monomer was incorporated into poly(N-isopropylacrylamide-co-methacrylic acid) nanogels for use as protein receptors. The aldehyde component forms dynamic imines with surface exposed lysine residues, while carboxylic acid/carboxylate moieties form electrostatic interactions with high isoelectric point proteins. Together, these interactions effect protein adsorption and recognition.

Graphical abstract: Nanogel receptors for high isoelectric point protein detection: influence of electrostatic and covalent polymer–protein interactions

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Article information

DOI
https://doi.org/10.1039/D0CC02200D
Article type
Communication
Submitted
27 Mar 2020
Accepted
28 Apr 2020
First published
28 Apr 2020

Chem. Commun., 2020,56, 6141-6144

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Nanogel receptors for high isoelectric point protein detection: influence of electrostatic and covalent polymer–protein interactions

M. E. Wechsler, H. K. H. J. Dang, S. D. Dahlhauser, S. P. Simmonds, J. F. Reuther, J. M. Wyse, A. N. VandeWalle, E. V. Anslyn and N. A. Peppas, Chem. Commun., 2020, 56, 6141 DOI: 10.1039/D0CC02200D

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