Issue 46, 2020
From the journal:

Chemical Communications

Deep imaging for visualizing nitric oxide in lipid droplets: discovering the relationship between nitric oxide and resistance to cancer chemotherapy drugs†

Miantai Ye,a   Wei Hu,b   Meng He,a   Chenchen Li,c   Shuyang Zhai,b   Zhihong Liu, ORCID logo bd   Yanying Wang,a   Huijuan Zhang*a  and  Chunya Li ORCID logo *ad  

* Corresponding authors

a Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, College of Chemistry and Material Science, South-central University for Nationalities, Wuhan 430074, China
E-mail: zhjminda@mail.scuec.edu.cn, lichychem@mail.scuec.edu.cn

b Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China

c Hubei Key Laboratory of Biological Resources Protection and Utilization, Hubei University for Nationalities, Enshi, China

d Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China

Abstract

A near-infrared two-photon fluorescent probe (TAN) was synthesized for selective detection and deep-depth imaging of NO in lipid droplets. All results demonstrated that NO production in lipid droplets is closely correlated with the resistance to anti-tumor drugs, and NO inhibitors can effectively improve the efficacy of chemotherapeutic agents.

Graphical abstract: Deep imaging for visualizing nitric oxide in lipid droplets: discovering the relationship between nitric oxide and resistance to cancer chemotherapy drugs

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Article information

DOI
https://doi.org/10.1039/D0CC01856B
Article type
Communication
Submitted
11 Mar 2020
Accepted
24 Apr 2020
First published
24 Apr 2020

Chem. Commun., 2020,56, 6233-6236

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Deep imaging for visualizing nitric oxide in lipid droplets: discovering the relationship between nitric oxide and resistance to cancer chemotherapy drugs

M. Ye, W. Hu, M. He, C. Li, S. Zhai, Z. Liu, Y. Wang, H. Zhang and C. Li, Chem. Commun., 2020, 56, 6233 DOI: 10.1039/D0CC01856B

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