Issue 41, 2020
From the journal:

Chemical Communications

A host–guest ATP responsive strategy for intracellular delivery of phosphopeptides†

Bei-Bei Han,‡ab   Yu-Chen Pan,‡c   Yan-Mei Li, ORCID logo ab   Dong-Sheng Guo ORCID logo *c  and  Yong-Xiang Chen ORCID logo *b  

* Corresponding authors

a Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China

b Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China
E-mail: chen-yx@mail.tsinghua.edu.cn

c College of Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
E-mail: dshguo@nankai.edu.cn

Abstract

We developed a host–guest ATP responsive strategy for efficient intracellular delivery of phosphopeptides, employing a pegylated arginine clustered calix[5]arene nanocarrier system that has great capability of recognizing the phosphate moieties on peptides and penetrating the cell membrane.

Graphical abstract: A host–guest ATP responsive strategy for intracellular delivery of phosphopeptides

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Article information

DOI
https://doi.org/10.1039/D0CC01800G
Article type
Communication
Submitted
09 Mar 2020
Accepted
07 Apr 2020
First published
07 Apr 2020

Chem. Commun., 2020,56, 5512-5515

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A host–guest ATP responsive strategy for intracellular delivery of phosphopeptides

B. Han, Y. Pan, Y. Li, D. Guo and Y. Chen, Chem. Commun., 2020, 56, 5512 DOI: 10.1039/D0CC01800G

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