A H2O2-free electrochemical peptide biosensor based on Au@Pt bimetallic nanorods for highly sensitive sensing of matrix metalloproteinase 2

Xiaoxue Xi; Meiqi Wen; Shihao Song; Junlun Zhu; Wei Wen; Xiuhua Zhang; Shengfu Wang

doi:10.1039/D0CC01598A

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A H₂O₂-free electrochemical peptide biosensor based on Au@Pt bimetallic nanorods for highly sensitive sensing of matrix metalloproteinase 2†

Xiaoxue Xi,^a Meiqi Wen,^a Shihao Song,^a Junlun Zhu,

^a Wei Wen,

*^a Xiuhua Zhang

^a and Shengfu Wang

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Biocatalysis and Enzyme Engineering & Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, People's Republic of China
E-mail: wenwei@hubu.edu.cn, wangsf@hubu.edu.cn

Abstract

Inspired by the excellent catalytic activity of Au@Pt bimetallic nanorods, we construct a H₂O₂-free electrochemical peptide biosensor based on Au@Pt bimetallic nanorods for highly efficient and sensitive sensing of MMP-2 for the first time, not only simplifying the traditional testing steps but also avoiding the potential damage caused by H₂O₂ to peptides and proteins.

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Article information

DOI: https://doi.org/10.1039/D0CC01598A
Article type: Communication
Submitted: 01 Mar 2020
Accepted: 29 Apr 2020
First published: 29 Apr 2020

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Chem. Commun., 2020,56, 6039-6042

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A H₂O₂-free electrochemical peptide biosensor based on Au@Pt bimetallic nanorods for highly sensitive sensing of matrix metalloproteinase 2

X. Xi, M. Wen, S. Song, J. Zhu, W. Wen, X. Zhang and S. Wang, Chem. Commun., 2020, 56, 6039 DOI: 10.1039/D0CC01598A

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Chemical Communications