Stimuli-responsive flexible Lewis pair-modified nanoparticles for fluorescence imaging

Abstract

A stimuli-responsive fluorophore, encompassing a Lewis acid–base pair, binds to primary amines on mesoporous silica nanoparticles, which may serve as environment-sensitive drug carriers. The fluorophore switches conformation, exhibiting different emission color and lifetimes, allowing for the detection of the water content of the nanoparticles’ surroundings through fluorescence spectroscopy and microscopy.