An efficient and facile strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes

Abstract

An effective and regioselective strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes was developed. By combination of TMSC_nF_2n+1 (n = 1, 2, 3) with PIFA, the method achieved the corresponding perfluoroalkylated products with broad functional group tolerance.