Sporormielones A–E, bioactive novel C–C coupled orsellinic acid derivative dimers, and their biosynthetic origin

Guo-Dong Chen; Dan Hu; Mei-Juan Huang; Jia Tang; Xiao-Xia Wang; Jian Zou; Jun Xie; Wei-Guang Zhang; Liang-Dong Guo; Xin-Sheng Yao; Ikuro Abe; Hao Gao

doi:10.1039/D0CC00855A

Sporormielones A–E, bioactive novel C–C coupled orsellinic acid derivative dimers, and their biosynthetic origin†

Guo-Dong Chen,‡^a Dan Hu,

‡^a Mei-Juan Huang,‡^a Jia Tang,^a Xiao-Xia Wang,^a Jian Zou,^a Jun Xie,^a Wei-Guang Zhang,^b Liang-Dong Guo,^c Xin-Sheng Yao,

*^a Ikuro Abe

*^d and Hao Gao

*^a

Author affiliations

* Corresponding authors

^a Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China
E-mail: tghao@jnu.edu.cn, tyaoxs@jnu.edu.cn

^b School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China

^c State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China

^d Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo113-003, Japan
E-mail: abei@mol.f.u-tokyo.ac.jp

Abstract

Sporormielones A–E (1–5), novel C–C coupled orsellinic acid derivative dimers containing tricyclic cores with a dimethylcyclopentenone unit, were obtained, of which 1–3 and 5 showed obvious short-term memory improvement activity in AD flies. Based on transcriptome analysis, ¹³C labelling, and gene deletion, their plausible biosynthetic mechanism was proposed.

Chemical Communications

Sporormielones A–E, bioactive novel C–C coupled orsellinic acid derivative dimers, and their biosynthetic origin†

Abstract

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Sporormielones A–E, bioactive novel C–C coupled orsellinic acid derivative dimers, and their biosynthetic origin

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