The biothiol-triggered organotrisulfide-based self-immolative fluorogenic donors of hydrogen sulfide enable lysosomal trafficking

Abstract

Biothiol-reactive organotrisulfide-based self-immolative fluorogenic donors of H₂S are rationally designed for the efficient monitoring of intracellular and lysosomal trafficking of H₂S with a concomitant turn-on fluorescence. The non-toxic nature of the donors with a sustained release of H₂S will certainly be helpful for their biomedical applications in the future.