Inhibition of 3D colon cancer stem cell spheroids by cytotoxic RuII-p-cymene complexes of mesalazine derivatives

Sourav Acharya; Subhashis Ghosh; Moumita Maji; Ajmal Roshan Unniram Parambil; Sandeep Singh; Arindam Mukherjee

doi:10.1039/D0CC00472C

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Inhibition of 3D colon cancer stem cell spheroids by cytotoxic Ru^II-p-cymene complexes of mesalazine derivatives†

Sourav Acharya,

^a Subhashis Ghosh,^b Moumita Maji,

^a Ajmal Roshan Unniram Parambil,^a Sandeep Singh*^b and Arindam Mukherjee

*^a

Author affiliations

* Corresponding authors

^a Department of Chemical Sciences and Centre for Advance Functional Materials (CAFM), Indian Institute of Science Education and Research Kolkata, Mohanpur, Nadia, West Bengal 741246, India
E-mail: a.mukherjee@iiserkol.ac.in

^b National Institute of Biomedical and Genomics, Kalyani, West Bengal 741251, India
E-mail: ss5@nibmg.ac.in

Abstract

The Ru(II) complex of an imidazole–mesalazine Schiff base is a unique example showing growth inhibition of 3D-colon cancer stem cell spheroids and bulk colon cancer cells at lower dosage than salinomycin or oxaliplatin. Unlike oxaliplatin which increases the expression of stemness genes (SOX2, KLF4, HES1 and Oct4), these complexes maintain a tight regulation.

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Article information

DOI: https://doi.org/10.1039/D0CC00472C
Article type: Communication
Submitted: 20 Jan 2020
Accepted: 01 Apr 2020
First published: 03 Apr 2020

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Chem. Commun., 2020,56, 5421-5424

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Inhibition of 3D colon cancer stem cell spheroids by cytotoxic Ru^II-p-cymene complexes of mesalazine derivatives

S. Acharya, S. Ghosh, M. Maji, A. R. U. Parambil, S. Singh and A. Mukherjee, Chem. Commun., 2020, 56, 5421 DOI: 10.1039/D0CC00472C

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