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Chemoenzymatic, Biomimetic Total Synthesis of (‒)-Rugulosin B, C and Rugulin Analogues and its Biosynthetic Implications

Abstract

Herein, we report the chemoenzymatic synthesis of a heterodimeric, (–)-rugulosin B and homodimeric, (–)-rugulosin C and several rugulin analogues in three to four steps starting from anthraquinones. The work supports dimerization between variously substituted putative monomeric intermediates during the biosynthesis of naturally occurring (+)-rugulosin B and C.

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Article information


Submitted
16 Jan 2020
Accepted
13 Feb 2020
First published
13 Feb 2020

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

Chemoenzymatic, Biomimetic Total Synthesis of (‒)-Rugulosin B, C and Rugulin Analogues and its Biosynthetic Implications

A. Mondal, S. K. Singh, T. Manna and S. M. Husain, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/D0CC00406E

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