Issue 39, 2020
From the journal:

Chemical Communications

Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands†

Chriselle D. Braganza,a   Chihiro Motozono,b   Koh-Hei Sonoda,c   Sho Yamasaki,defg   Kensuke Shibata,*ceh   Mattie S. M. Timmer ORCID logo *a  and  Bridget L. Stocker*a  

* Corresponding authors

a School of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand
E-mail: mattie.timmer@vuw.ac.nz, bridget.stocker@vuw.ac.nz

b Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

c Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

d Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

e Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan

f Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan

g Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba 260-8673, Japan

h Systems Biochemistry in Pathology and Regeneration, Graduate School of Medicine, Yamaguchi University, Ube, Japan

Abstract

Mucosal-associated invariant T (MAIT) are a subset of innate-like T cells that are activated by uracil ligands presented by MR1. For the first time, we demonstrate that changes to the 6-aminoalkyl chain on uracil agonist 5-OP-RU can determine agonistic or antagonistic MAIT cell activity. Insomuch, a simplified agonist with a functional profile similar to 5-OP-RU, and a new structural class of antagonist that exhibits similar activity to known MAIT cell antagonist Ac-6-FP, were identified.

Graphical abstract: Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands

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Article information

DOI
https://doi.org/10.1039/D0CC00247J
Article type
Communication
Submitted
10 Jan 2020
Accepted
25 Mar 2020
First published
25 Mar 2020

Chem. Commun., 2020,56, 5291-5294

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Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands

C. D. Braganza, C. Motozono, K. Sonoda, S. Yamasaki, K. Shibata, M. S. M. Timmer and B. L. Stocker, Chem. Commun., 2020, 56, 5291 DOI: 10.1039/D0CC00247J

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