Issue 34, 2020

Visualization of penicillin G acylase in bacteria and high-throughput screening of natural inhibitors using a ratiometric fluorescent probe

Abstract

A ratiometric fluorescent probe (PNA) was developed to sense and image endogenous bacterial penicillin G acylase (PGA). Oleanolic acid was discovered as a potential natural inhibitor of PGA using high-throughput screening techniques based on PNA.

Graphical abstract: Visualization of penicillin G acylase in bacteria and high-throughput screening of natural inhibitors using a ratiometric fluorescent probe

Supplementary files

Article information

Article type
Communication
Submitted
08 Jan 2020
Accepted
24 Mar 2020
First published
24 Mar 2020
This article is Open Access
Creative Commons BY license

Chem. Commun., 2020,56, 4640-4643

Visualization of penicillin G acylase in bacteria and high-throughput screening of natural inhibitors using a ratiometric fluorescent probe

L. Li, L. Feng, M. Zhang, X. He, S. Luan, C. Wang, T. D. James, H. Zhang, H. Huang and X. Ma, Chem. Commun., 2020, 56, 4640 DOI: 10.1039/D0CC00197J

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