Issue 20, 2020

The affinity of RSK for cylitol analogues of SL0101 is critically dependent on the B-ring C-4′-hydroxy

Abstract

Five cyclitol analogues of SL0101 with variable substitution at the C-4′ position (i.e., OH, Cl, F, H, OMe) were synthesized. The series of analogues were evaluated for their ability to inhibit p90 ribosomal S6 kinase (RSK) activity. The study demonstrated the importance of the B-ring C-4′ hydroxy group for RSK1/2 inhibition.

Graphical abstract: The affinity of RSK for cylitol analogues of SL0101 is critically dependent on the B-ring C-4′-hydroxy

Supplementary files

Article information

Article type
Communication
Submitted
07 Jan 2020
Accepted
29 Jan 2020
First published
29 Jan 2020

Chem. Commun., 2020,56, 3058-3060

Author version available

The affinity of RSK for cylitol analogues of SL0101 is critically dependent on the B-ring C-4′-hydroxy

Y. Li, P. Seber, E. B. Wright, S. Yasmin, D. A. Lannigan and G. A. O'Doherty, Chem. Commun., 2020, 56, 3058 DOI: 10.1039/D0CC00128G

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