Issue 16, 2020

A superior G-quadruplex DNAzyme through functionalized modification of the hemin cofactor

Abstract

Unlike previous studies that are generally based on the native cofactor, chemical modifications of the hemin structure through introducing new functionalities are proposed to enhance the catalytic efficiency of the hemin/G-quadruplex (hG4) DNAzyme. Functionalized hemin cofactors will highly improve the performance of the hG4 DNAzyme in future applications.

Graphical abstract: A superior G-quadruplex DNAzyme through functionalized modification of the hemin cofactor

Supplementary files

Article information

Article type
Communication
Submitted
17 Dec 2019
Accepted
21 Jan 2020
First published
21 Jan 2020

Chem. Commun., 2020,56, 2427-2430

A superior G-quadruplex DNAzyme through functionalized modification of the hemin cofactor

Y. Liu, P. Lai, J. Wang, X. Xing and L. Xu, Chem. Commun., 2020, 56, 2427 DOI: 10.1039/C9CC09729E

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