Issue 27, 2020
From the journal:

Chemical Communications

l-Cysteine decorated nanoscale metal–organic frameworks delivering valproic acid/cisplatin for drug-resistant lung cancer therapy†

Wenna Guo,ab   Zengzhen Chen,ac   Longfei Tan,*a   Qiong Wu,a   Xiangling Ren,a   Changhui Fu,a   Yongxing Du,*b   Jun Rena  and  Xianwei Meng ORCID logo *a  

* Corresponding authors

a Laboratory of Controllable Preparation and Application of Nanomaterials, Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, No. 29 East Road Zhongguancun, Beijing 100190, P. R. China
E-mail: mengxw@mail.ipc.ac.cn, longfeitan@mail.ipc.ac.cn

b School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou 014010, China
E-mail: dyxql@imust.edu.cn

c University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Abstract

We design multifunctional CDDP-VPA@ZrMOF-Cys-PEG nanoparticles (CVZP NPs) based on the properties of valproic acid (VPA) that can downregulate the expression of vascular endothelial growth factor (VEGF) to reduce the drug resistance of tumor cells. In vivo experiments confirm that chemotherapy combined with microwave thermal therapy (MWTT) can significantly improve the therapeutic effect of cisplatin-resistant lung cancer.

Graphical abstract: l-Cysteine decorated nanoscale metal–organic frameworks delivering valproic acid/cisplatin for drug-resistant lung cancer therapy

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Article information

DOI
https://doi.org/10.1039/C9CC09712K
Article type
Communication
Submitted
14 Dec 2019
Accepted
28 Feb 2020
First published
28 Feb 2020

Chem. Commun., 2020,56, 3919-3922

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L-Cysteine decorated nanoscale metal–organic frameworks delivering valproic acid/cisplatin for drug-resistant lung cancer therapy

W. Guo, Z. Chen, L. Tan, Q. Wu, X. Ren, C. Fu, Y. Du, J. Ren and X. Meng, Chem. Commun., 2020, 56, 3919 DOI: 10.1039/C9CC09712K

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