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Issue 17, 2020
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Substrate interaction inhibits γ-secretase production of amyloid-β peptides

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Abstract

Combining NMR, mass spectrometry, AlphaLISA and cell assays, we discovered a compound C1 that binds C-terminal juxtamembrane lysines at the transmembrane domain of the amyloid precursor protein (APPTM) and inhibits γ-secretase production of amyloid-β with μM IC50. Our work suggests that targeting APPTM is a novel and viable strategy in AD drug discovery.

Graphical abstract: Substrate interaction inhibits γ-secretase production of amyloid-β peptides

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Supplementary files

Article information


Submitted
25 Nov 2019
Accepted
08 Jan 2020
First published
03 Feb 2020

This article is Open Access

Chem. Commun., 2020,56, 2578-2581
Article type
Communication

Substrate interaction inhibits γ-secretase production of amyloid-β peptides

J. Zhao, Y. Xiao, X. Liu, S. Kim, X. Wu, M. Barros, R. Zhuang, X. Hou, Y. Zhang, N. K. Robakis, Y. Li, J. S. Dordick, I. Ubarretxena-Belandia and C. Wang, Chem. Commun., 2020, 56, 2578
DOI: 10.1039/C9CC09170J

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