Issue 2, 2020
From the journal:

Chemical Communications

Peptide-templated gold nanoparticle nanosensor for simultaneous detection of multiple posttranslational modification enzymes†

Dandan Zhang,‡a   Ya-ru Meng‡a  and  Chun-yang Zhang ORCID logo *a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, China
E-mail: cyzhang@sdnu.edu.cn
Fax: +86-0531-82615258
Tel: +86-0531-86186033

Abstract

We developed a peptide-templated gold nanoparticle (AuNP) nanosensor for simultaneous detection of multiple posttranslational modification (PTM) enzymes with a detection limit of 28 pM for histone deacetylase (HDAC) and 0.8 pM for protein tyrosine phosphatase 1B (PTP1B), and it can be further applied for the screening of PTM enzyme inhibitors and the measurement of PTM enzymes in cancer cells.

Graphical abstract: Peptide-templated gold nanoparticle nanosensor for simultaneous detection of multiple posttranslational modification enzymes

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Article information

DOI
https://doi.org/10.1039/C9CC09019C
Article type
Communication
Submitted
19 Nov 2019
Accepted
29 Nov 2019
First published
29 Nov 2019

Chem. Commun., 2020,56, 213-216

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Peptide-templated gold nanoparticle nanosensor for simultaneous detection of multiple posttranslational modification enzymes

D. Zhang, Y. Meng and C. Zhang, Chem. Commun., 2020, 56, 213 DOI: 10.1039/C9CC09019C

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