Visualization of the cysteine level during Golgi stress using a novel Golgi-targeting highly specific fluorescent probe

Xue Zhang; Caiyun Liu; Yanan Chen; Xinyu Cai; Wenlong Sheng; Hanchuang Zhu; Pan Jia; Zilu Li; Shengyun Huang; Baocun Zhu

doi:10.1039/C9CC08796F

Visualization of the cysteine level during Golgi stress using a novel Golgi-targeting highly specific fluorescent probe†

Xue Zhang,^a Caiyun Liu,

*^a Yanan Chen,^a Xinyu Cai,^a Wenlong Sheng,*^b Hanchuang Zhu,^a Pan Jia,^a Zilu Li,^a Shengyun Huang*^c and Baocun Zhu

*^a

Author affiliations

* Corresponding authors

^a School of Water Conservancy and Environment, University of Jinan, Jinan 250022, China
E-mail: liucaiyun1982072@163.com, lcyzbc@163.com

^b Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China
E-mail: 15618694162@163.com

^c Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
E-mail: huangsy28@163.com

Abstract

A novel Golgi-targeting Cys-specific fluorescent probe (Gol-Cys) was synthesized. Probe Gol-Cys is not only sufficiently sensitive to native Cys in living cells and zebrafish, but also can be used for monitoring the Cys level during Golgi stress.

Chemical Communications

Visualization of the cysteine level during Golgi stress using a novel Golgi-targeting highly specific fluorescent probe†

Abstract

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Visualization of the cysteine level during Golgi stress using a novel Golgi-targeting highly specific fluorescent probe

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