Issue 11, 2020
From the journal:

Chemical Communications

A functionalized dumbbell probe-based cascading exponential amplification DNA machine enables amplified probing of microRNAs†

Jie Wang,a   Shuhui Li,a   Jianguo Xu, ORCID logo *b   Yusheng Lu,c   Min Lin,a   Chaihung Wang,a   Chen Zhang,c   Guoxing Lina  and  Lee Jia ORCID logo *ac  

* Corresponding authors

a Cancer Metastasis Alert and Prevention Center, and Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention, College of Chemistry, Fuzhou University, Fuzhou 350002, China

b School of Food and Biological Engineering, Hefei University of Technology, Hefei, China
E-mail: jgxu0816@163.com

c Institute of Oceanography, Minjiang University, Fuzhou, Fujian 350108, China
E-mail: cmapcjia1234@163.com

Abstract

A functionalized dumbbell probe (FDP) based amplification method, termed as a cascading exponential amplification DNA machine (CEA-DNA machine), has been developed to autonomously accumulate single G-quadruplexes (SGQs) and twin-G-quadruplexes (TGQs) for robust fluorescence signal-on probing of miRNA-21.

Graphical abstract: A functionalized dumbbell probe-based cascading exponential amplification DNA machine enables amplified probing of microRNAs

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Article information

DOI
https://doi.org/10.1039/C9CC08289A
Article type
Communication
Submitted
22 Oct 2019
Accepted
06 Jan 2020
First published
06 Jan 2020

Chem. Commun., 2020,56, 1681-1684

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A functionalized dumbbell probe-based cascading exponential amplification DNA machine enables amplified probing of microRNAs

J. Wang, S. Li, J. Xu, Y. Lu, M. Lin, C. Wang, C. Zhang, G. Lin and L. Jia, Chem. Commun., 2020, 56, 1681 DOI: 10.1039/C9CC08289A

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