Issue 7, 2020
From the journal:

Chemical Communications

Simultaneous imaging of mitochondrial viscosity and hydrogen peroxide in Alzheimer's disease by a single near-infrared fluorescent probe with a large Stokes shift†

Songjiao Li,a   Peipei Wang,a   Wenqi Feng,a   Yunhui Xiang,a   Kun Doua  and  Zhihong Liu ORCID logo *a  

* Corresponding authors

a Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China
E-mail: zhhliu@whu.edu.cn
Fax: +86-27-6875-4067
Tel: +86-27-8721-7886

Abstract

It has been speculated that both the intracellular viscosity and H2O2 level in Alzheimer's disease (AD) brains are higher than that in healthy brains, but direct evidence from living beings is scarce. Herein, we report a NIR emissive fluorescent probe with a large Stokes shift for the associated detection of mitochondrial viscosity and H2O2 in live rat brains with AD for the first time.

Graphical abstract: Simultaneous imaging of mitochondrial viscosity and hydrogen peroxide in Alzheimer's disease by a single near-infrared fluorescent probe with a large Stokes shift

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Article information

DOI
https://doi.org/10.1039/C9CC08267K
Article type
Communication
Submitted
22 Oct 2019
Accepted
12 Dec 2019
First published
15 Dec 2019

Chem. Commun., 2020,56, 1050-1053

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Simultaneous imaging of mitochondrial viscosity and hydrogen peroxide in Alzheimer's disease by a single near-infrared fluorescent probe with a large Stokes shift

S. Li, P. Wang, W. Feng, Y. Xiang, K. Dou and Z. Liu, Chem. Commun., 2020, 56, 1050 DOI: 10.1039/C9CC08267K

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