Jump to main content
Jump to site search

Issue 17, 2020
Previous Article Next Article

Paper spray mass spectrometry utilizing Teslin® substrate for rapid detection of lipid metabolite changes during COVID-19 infection

Author affiliations

Abstract

The SARS-CoV-2 virus is known as the causal agent for the current COVID-19 global pandemic. The majority of COVID-19 patients develop acute respiratory distress syndrome (ARDS), while some experience a cytokine storm effect, which is considered as one of the leading causes of patient mortality. Lipids are known to be involved in the various stages of the lifecycle of a virus functioning as receptors or co-receptors that controls viral propagation inside the host cell. Therefore, lipid-related metabolomics aims to provide insight into the immune response of the novel coronavirus. Our study has focused on determination of the potential metabolomic biomarkers utilizing a Teslin® Substrate in paper spray mass spectrometry (PS-MS) for the development of a rapid detection test within 60 seconds of analysis time. In this study, results were correlated with PCR tests to reflect that the systemic responses of the cells were affected by the COVID-19 virus.

Graphical abstract: Paper spray mass spectrometry utilizing Teslin® substrate for rapid detection of lipid metabolite changes during COVID-19 infection

Back to tab navigation

Supplementary files

Article information


Submitted
28 May 2020
Accepted
10 Jul 2020
First published
16 Jul 2020

Analyst, 2020,145, 5725-5732
Article type
Communication

Paper spray mass spectrometry utilizing Teslin® substrate for rapid detection of lipid metabolite changes during COVID-19 infection

I. W. De Silva, S. Nayek, V. Singh, J. Reddy, J. K. Granger and G. F. Verbeck, Analyst, 2020, 145, 5725
DOI: 10.1039/D0AN01074J

Social activity

Search articles by author

Spotlight

Advertisements