Issue 4, 2019

Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use

Abstract

Paracetamol poisoning was first reported in 1966. The development of antidotes followed within 10 years, and by 1980 acetylcysteine (NAC) was acknowledged as the optimal therapy available. This article examines the history of the development of NAC and recent developments in its use. We offer suggestions for improvements in the way NAC may be administered and outline new developments that should have major impacts on the way we manage paracetamol poisoning in the near future.

Graphical abstract: Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use

Associated articles

Article information

Article type
Review Article
Submitted
07 Jan 2019
Accepted
26 Apr 2019
First published
29 Apr 2019
This article is Open Access
Creative Commons BY-NC license

Toxicol. Res., 2019,8, 489-498

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