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Issue 43, 2019
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Light-controllable systems based on TiO2-ZIF-8 composites for targeted drug release: communicating with tumour cells

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Abstract

Drug delivery systems based on the zeolitic imidazolate framework ZIF-8 have recently attracted viable research interest owing to their capability of decomposing in acidic media and thus performing targeted drug delivery. In vivo realization of this mechanism faces a challenge of relatively slow decomposition rates, even at elevated acidic conditions that are barely achievable in diseased tissues. In this study we propose to combine drug delivery nanocomposites with a semiconductor photocatalytic agent that would be capable of inducing a local pH gradient in response to external electromagnetic radiation. In order to test this principle, a model drug-releasing nanocomposite comprising photocatalytic titania nanotubes, ZIF-8, and the antitumor drug doxorubicin has been investigated. This system was demonstrated to release the drug in a quantity sufficient for effectively suppressing IMR-32 neuroblastoma cells that were used as a model diseased tissue. With locally applied UV irradiation, this result was achieved within 40 minutes, which is a relatively short time compared to the release duration in systems without photocatalyst, typically taking from several hours to several days.

Graphical abstract: Light-controllable systems based on TiO2-ZIF-8 composites for targeted drug release: communicating with tumour cells

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Publication details

The article was received on 05 Jul 2019, accepted on 02 Oct 2019 and first published on 03 Oct 2019


Article type: Paper
DOI: 10.1039/C9TB01377F
J. Mater. Chem. B, 2019,7, 6810-6821

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    Light-controllable systems based on TiO2-ZIF-8 composites for targeted drug release: communicating with tumour cells

    A. Sharsheeva, V. A. Iglin, P. V. Nesterov, O. A. Kuchur, E. Garifullina, E. Hey-Hawkins, S. A. Ulasevich, E. V. Skorb, A. V. Vinogradov and M. I. Morozov, J. Mater. Chem. B, 2019, 7, 6810
    DOI: 10.1039/C9TB01377F

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