Jump to main content
Jump to site search

Issue 23, 2019
Previous Article Next Article

Identification of fatty liver disease at diverse stages using two-photon absorption of triphenylamine-based BODIPY analogues

Author affiliations

Abstract

Fatty liver disease (FLD) is one of the major hazards to human health, but effectively and accurately detecting it during its various phases remains challenging. To address this issue, in the current work, four BODIPY analogues (01B–04B) with different donor/acceptor groups were rationally designed. Photophysical and theoretical studies demonstrated an obvious intramolecular charge transfer (ICT) in 03B, with two-photon action cross-sections up to 198 GM in the near-infrared region. An initial in vitro assessment indicated that 03B could interact with the lipid substances with a significant fluorescence enhancement. Due to its high biocompatibility, lipid affinity, and sensitivity, 03B could target model 3T3-L1 cells at various FLD-induced stages. Furthermore, an in vivo study demonstrated the ability to use 03B to clearly distinguish FLD tissue and display a lesion in situ. These results offered a promising optical tool for evaluating FLD at various phases and monitoring its dynamics at the sub-cellular level.

Graphical abstract: Identification of fatty liver disease at diverse stages using two-photon absorption of triphenylamine-based BODIPY analogues

Back to tab navigation

Supplementary files

Article information


Submitted
01 Mar 2019
Accepted
03 May 2019
First published
10 May 2019

J. Mater. Chem. B, 2019,7, 3704-3709
Article type
Paper

Identification of fatty liver disease at diverse stages using two-photon absorption of triphenylamine-based BODIPY analogues

T. Shao, T. Liu, H. Liu, M. Zhang, Y. Shen, A. Gao, X. Tian, Q. Zhang, J. Wu and Y. Tian, J. Mater. Chem. B, 2019, 7, 3704
DOI: 10.1039/C9TB00421A

Social activity

Search articles by author

Spotlight

Advertisements