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Issue 11, 2019
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Photo-triggerable liposomal drug delivery systems: from simple porphyrin insertion in the lipid bilayer towards supramolecular assemblies of lipid–porphyrin conjugates

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Abstract

Light-responsive liposomes are considered nowadays as one of the most promising nanoparticulate systems for the delivery and release of an active pharmaceutical ingredient (API) in a spatio-temporal manner. Several strategies can be used to design photo-triggered liposomes. One of them consists in the incorporation of a photosensitizer (PS) in the lipid matrix of a liposomal bilayer that induces the release of the cargo either via a photochemical or a photophysical process. Among the described photosensitizers, porphyrin derivatives have appeared as the most potent ones. This review describes the state-of-the-art of photo-triggerable liposomes based on the combination of lipids and porphyrin derivatives either free or conjugated. It focuses on the different light-triggered release mechanisms and the requirements for the development of such systems. It also details the different strategies for the synthesis of lipid–porphyrin conjugates, their self-assembling properties and their biomedical applications.

Graphical abstract: Photo-triggerable liposomal drug delivery systems: from simple porphyrin insertion in the lipid bilayer towards supramolecular assemblies of lipid–porphyrin conjugates

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Publication details

The article was received on 03 Jan 2019, accepted on 09 Feb 2019 and first published on 18 Feb 2019


Article type: Review Article
DOI: 10.1039/C9TB00015A
J. Mater. Chem. B, 2019,7, 1805-1823

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    Photo-triggerable liposomal drug delivery systems: from simple porphyrin insertion in the lipid bilayer towards supramolecular assemblies of lipid–porphyrin conjugates

    J. Massiot, V. Rosilio and A. Makky, J. Mater. Chem. B, 2019, 7, 1805
    DOI: 10.1039/C9TB00015A

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