Jump to main content
Jump to site search


Stimuli-Responsive Multifunctional Metal-Organic Framework Nanoparticles for Enhanced Chemo-Photothermal Therapy

Abstract

Construction of stimuli-responsive multifunctional nanoparticles is critical for nanotherapeutic delivery. Though metal-organic frameworks (MOFs) have emerged as promising delivery vehicles, therapeutic efficacy of MOF for cancer treatment is limited by the lack of general approach for the preparation of stimuli-responsive multifunctional MOFs. We show that combination of a versatile coating material polydopamine with MOFs enables facile integration of different functional therapeutics, obtaining stimuli-responsive multifunctional MOFs with extensive photothermal efficiency and outstanding capability to abrogate tumor by chemo-photothermal therapy. Exemplary MOFs including ZIF-8, UiO-66, and MIL-101 were utilized to prepare stimuli-responsive multifunctional MOFs to illustrate the generality of the strategy. This approach enables targeted drug delivery, stimuli-responsive release of multi-therapeutics, and allows combination therapy with excellent in vitro and in vivo antitumor activity. Taking into account the diversity of MOFs and different functional molecules, this work provides flexible access to programmable MOF nanoparticles for specific biological applications.

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Oct 2018, accepted on 06 Jan 2019 and first published on 08 Jan 2019


Article type: Paper
DOI: 10.1039/C8TB02815J
Citation: J. Mater. Chem. B, 2019, Accepted Manuscript
  •   Request permissions

    Stimuli-Responsive Multifunctional Metal-Organic Framework Nanoparticles for Enhanced Chemo-Photothermal Therapy

    J. Feng, Z. Xu, P. Dong, W. Yu, F. Liu, Q. Jiang, F. Wang and X. Liu, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C8TB02815J

Search articles by author

Spotlight

Advertisements