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Perfluorocarbon-based O2 nanocarrier for efficient photodynamic therapy

Abstract

Tumor hypoxia has been considered as one of the major factors that limits the efficiency of photodynamic therapy (PDT), in which oxygen is needed to generate singlet oxygen for cell destruction. Inspired by the excellent O2 carrying ability of perfluorocarbon molecules in artificial blood, we perpared a series of polymer micelles with perfluorocarbon core to carry both photo-sensitizer and O2 to the tumor site, aiming to improve PDT efficiency. We found that the accelerated generation of 1O2 correleted with the increased perfluorocarbon amount. In vitro cell study further showed that the new perfluorocarbon formulation not only improved the production of 1O2, thereby enhancing the photodynamic therapy efficiency, but also significantly reduced cell toxicity when compared with the one without these perfluoro units. This work provides a new option for improving PDT efficiency with the new perfluorocarbon-incorporated nanoplatform.

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Publication details

The article was received on 15 Jul 2018, accepted on 14 Jan 2019 and first published on 14 Jan 2019


Article type: Paper
DOI: 10.1039/C8TB01844H
Citation: J. Mater. Chem. B, 2019, Accepted Manuscript
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    Perfluorocarbon-based O2 nanocarrier for efficient photodynamic therapy

    H. Hu, X. Yan, H. Wang, T. Joji, M. Wang, W. You and Z. Li, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C8TB01844H

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