Jump to main content
Jump to site search

Issue 45, 2019
Previous Article Next Article

DNA-based long-lived reaction–diffusion patterning in a host hydrogel

Author affiliations


The development of living organisms is a source of inspiration for the creation of synthetic life-like materials. Embryo development is divided into three stages that are inextricably linked: patterning, differentiation and growth. During patterning, sustained out-of-equilibrium molecular programs interpret underlying molecular cues to create well-defined concentration profiles. Implementing this patterning stage in an autonomous synthetic material is a challenge that at least requires a programmable and long-lasting out-of-equilibrium chemistry compatible with a host material. Here, we show that DNA/enzyme reactions can create reaction–diffusion patterns that are extraordinarily long-lasting both in solution and inside an autonomous hydrogel. The life-time and stability of these patterns – here, traveling fronts and two-band patterns – are significantly increased by blocking parasitic side reactions and by dramatically reducing the diffusion coefficient of specific DNA strands. Immersed in oil, hydrogels pattern autonomously with limited evaporation, but can also exchange chemical information with other gels when brought into contact. Providing a certain degree of autonomy and being capable of interacting with each other, we believe these out-of-equilibrium hydrogels open the way for the rational design of primitive metabolic materials.

Graphical abstract: DNA-based long-lived reaction–diffusion patterning in a host hydrogel

Back to tab navigation

Supplementary files

Article information

03 Sep 2019
19 Oct 2019
First published
21 Oct 2019

Soft Matter, 2019,15, 9343-9351
Article type

DNA-based long-lived reaction–diffusion patterning in a host hydrogel

G. Urtel, A. Estevez-Torres and J. Galas, Soft Matter, 2019, 15, 9343
DOI: 10.1039/C9SM01786K

Social activity

Search articles by author