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Bending rigidity of charged lipid bilayer membranes

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Abstract

We experimentally investigate the effect of lipid charge on the stiffness of bilayer membranes. The bending rigidity of membranes with composition 0–100 mol% of charged lipids, in the absence and presence of salt at different concentrations, is measured with the flicker spectroscopy method, using the shape fluctuations of giant unilamellar vesicles. The analysis considers both the mean squared amplitudes and the time autocorrelations of the shape modes. Our results show that membrane charge increases the bending rigidity relative to the charge-free membrane. The effect is diminished by the addition of monovalent salt to the suspending solutions. The trend shown by the membrane bending rigidity correlates with zeta potential measurements, confirming charge screening at different salt concentrations. The experimental results in the presence of salt are in good agreement with existing theories of membrane stiffening by surface charge.

Graphical abstract: Bending rigidity of charged lipid bilayer membranes

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Publication details

The article was received on 16 Apr 2019, accepted on 28 Jun 2019 and first published on 11 Jul 2019


Article type: Paper
DOI: 10.1039/C9SM00772E
Soft Matter, 2019, Advance Article
  • Open access: Creative Commons BY license
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    Bending rigidity of charged lipid bilayer membranes

    H. A. Faizi, S. L. Frey, J. Steinkühler, R. Dimova and P. M. Vlahovska, Soft Matter, 2019, Advance Article , DOI: 10.1039/C9SM00772E

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