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ATP Responsive DNA Nanogels Grown on Biocompatible Branches for Anticancer Drug

Abstract

We developed biocompatible ATP responsive DNA nanogels, by grafting DNA strands on carboxymethyl chitosan polymer chains, then hybridized by ATP aptamers to form core-shell nanogels. The DNA duplex structure could embed DOX in the G-C sequences, and realize simultaneous sol-gel transition and DOX release by touching on the “ATP swift”.

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Publication details

The article was received on 08 Mar 2019, accepted on 14 Apr 2019 and first published on 15 Apr 2019


Article type: Communication
DOI: 10.1039/C9SM00480G
Citation: Soft Matter, 2019, Accepted Manuscript

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    ATP Responsive DNA Nanogels Grown on Biocompatible Branches for Anticancer Drug

    M. Zhao, Y. Zhang, S. Yuan, X. Xu, Z. Wu, Z. Wu and X. Qi, Soft Matter, 2019, Accepted Manuscript , DOI: 10.1039/C9SM00480G

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