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Collective stresses drive competition between monolayers of normal and Ras-transformed cells

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Abstract

We study the competition for space between two cell lines that differ only in the expression of the Ras oncogene. The two cell populations are initially separated and set to migrate antagonistically towards an in-between stripe of free substrate. After contact, their interface moves towards the population of normal cells. We interpret the velocity and traction force data taken before and after contact thanks to a hydrodynamic description of collectively migrating cohesive cell sheets. The kinematics of cells, before and after contact, allows us to estimate the relative material parameters for both cell lines. As predicted by the model, the transformed cell population with larger collective stresses pushes the wild type cell population.

Graphical abstract: Collective stresses drive competition between monolayers of normal and Ras-transformed cells

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Publication details

The article was received on 26 Jul 2018, accepted on 15 Nov 2018 and first published on 05 Dec 2018


Article type: Paper
DOI: 10.1039/C8SM01523F
Citation: Soft Matter, 2019, Advance Article
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    Collective stresses drive competition between monolayers of normal and Ras-transformed cells

    S. Moitrier, C. Blanch-Mercader, S. Garcia, K. Sliogeryte, T. Martin, J. Camonis, P. Marcq, P. Silberzan and I. Bonnet, Soft Matter, 2019, Advance Article , DOI: 10.1039/C8SM01523F

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