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A transition-metal-free & diazo-free styrene cyclopropanation

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Abstract

An operationally simple and broadly applicable novel cyclopropanation of styrenes using gem-diiodomethyl carbonyl reagents has been developed. Visible-light triggered the photoinduced generation of iodomethyl carbonyl radicals, able to cyclopropanate a wide array of styrenes with excellent chemoselectivity and functional group tolerance. To highlight the utility of our photocyclopropanation, we demonstrated the late-stage functionalization of biomolecule derivatives.

Graphical abstract: A transition-metal-free & diazo-free styrene cyclopropanation

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Publication details

The article was received on 05 Jun 2019, accepted on 17 Aug 2019 and first published on 28 Aug 2019


Article type: Edge Article
DOI: 10.1039/C9SC02749A
Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    A transition-metal-free & diazo-free styrene cyclopropanation

    A. G. Herraiz and M. G. Suero, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C9SC02749A

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