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Cobalt-Catalyzed Acylation-Reactions of (Hetero)Arylzinc Pivalates with Thiopyridyl Ester Derivatives

Abstract

A cobalt-catalyzed acylation reaction of various primary, secondary and tertiary alkyl, benzyl and (hetero)aryl S-pyridyl thioesters with (hetero)aryl zinc pivalates is reported. The thioesters were prepared directly from the corresponding carboxylic acids under mild conditions, thus tolerating sensitive functional groups. Acylations of α-chiral S-pyridyl esters proceeded with very high stereoretention leading to optically enriched α-chiral ketones.

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Publication details

The article was received on 12 Apr 2019, accepted on 09 Jul 2019 and first published on 11 Jul 2019


Article type: Edge Article
DOI: 10.1039/C9SC01817D
Chem. Sci., 2019, Accepted Manuscript
  • Open access: Creative Commons BY-NC license
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    Cobalt-Catalyzed Acylation-Reactions of (Hetero)Arylzinc Pivalates with Thiopyridyl Ester Derivatives

    F. H. Lutter, L. Grokenberger, M. S. Hofmayer and P. Knochel, Chem. Sci., 2019, Accepted Manuscript , DOI: 10.1039/C9SC01817D

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